1,559 research outputs found

    Perfective and Imperfective in French Kinds of abilities and Actuality Entailment (And some notes on epistemic readings)

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    Possibility Modals: abilities and epistemic readings (French)

    Generic Sentences and Types of Judgments

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    This paper investiagtes the correlation between the meaning of the plural indefinite 'des' and the plural definite 'les' in French and their ability to express different types of generic statements. It argues that the main feature that distinguishes these two items is the (non)-novelty, in a Heimian framework

    Lithium: a key to the genetics of bipolar disorder

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    Since the 1950s, lithium salts have been the main line of treatment for bipolar disorder (BD), both as a prophylactic and as an episodic treatment agent. Like many psychiatric conditions, BD is genetically and phenotypically heterogeneous, but evidence suggests that individuals who respond well to lithium treatment have more homogeneous clinical and molecular profiles. Response to lithium seems to cluster in families and can be used as a predictor for recurrence of BD symptoms. While molecular studies have provided important information about possible genes involved in BD predisposition or in lithium response, neither the mechanism of action of this drug nor the genetic profile of bipolar disorder is, as yet, completely understood

    Personalized psychiatry: many questions, fewer answers

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    Bare and indefinite NPs in predicative position in French

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    This paper proposes a new analysis of the use of bare nouns vs. indefinite NPs in predicative position in French. We distinguish between predicational sentences (with the bare noun version) and equative sentences (with the indefinite version). We argue that bare nouns ascribe permanent properties to aspects of entities. As for the indefinites, we claim that they exhibit their specific reading and introduce an individual in a new situation, which is identified with the referent of the subject

    Primer registro de Diphterostomum brusinae (Digenea, Zoogonidae) parasitando a la corvina Micropogonias furnieri con datos sobre su ciclo biológico

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    En un estudio que ampliará el conocimiento de los parásitos de peces de ambientes mixohalinos de Argentina, se hallaron ejemplares adultos de Diphterostomum brusinae parasitando el intestino de juveniles de la corvina, Micropogonias furnieri (Sciaenidae), en el estuario de Bahía Blanca (N = 142) y en la Bahía de Samborombón (N = 265) (provincia de Buenos Aires). Los valores de prevalencia (P) e intensidad media (IM) fueron mayores en el primer sitio (P = 18,3% vs 14,7%; IM = 18,9 vs 6,7). La morfología y las medidas de los especímenes concuerdan con aquellos brindados en la descripción original de D. brusinae. Los adultos se caracterizaron por poseer un tegumento espinoso, dos ciegos intestinales saculares y un acetábulo bien desarrollado con dos pares de labios musculares (uno anterior y otro posterior). En la Bahía de Samborombón también se hallaron estadios larvales (esporocistos, cercarias y metacercarias) parasitando al caracol Buccinanops globulosus (Nassariidae). La morfología y medidas de estos estadios también fueron coincidentes con los descritos anteriormente para D. brusinae. En este trabajo se reporta por primera vez D. brusinae en M. furnieri de Argentina y se propone parte del desarrollo de su ciclo de vida en la Bahía de Samborombón, Argentina.In a survey to increase the knowledge about parasites of fishes in brackish waters of Argentina, we found adult specimens of Diphterostomum brusinae parasitizing the gut of juveniles of the whitemouth croaker, Micropogonias furnieri (Sciaenidae), in Bahía Blanca estuary (N=142) and in Samborombón Bay (N=265) (Buenos Aires Province, Argentina). Prevalence (P) and mean intensity (MI) were higher in the first site (P = 18,3 % vs. 14,7 %; MI = 18,9 vs. 6,7). Measurements and morphology of specimens fits with the description previously made for D. brusinae. Adults typically have a densely spiny tegument, two small and sacular intestinal caeca, and a well-developed ventral sucker with two pairs of muscular lips. In Samborombón Bay we also found larval stages (sporocysts, cercariae, and metacercariae) parasitizing the intertidal snail Buccinanops globulosus (Nassariidae). The morphology and measurements are also coincident to those described for larvae stages of D. brusinae. In this work we record for the first time D. brusinae in M. furnieri from Argentina and partially propose the life cycle of this species in Samborombón Bay, Argentina.Fil: Martorelli, Sergio Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Estudios Parasitológicos y de Vectores (i); ArgentinaFil: Montes, Martin Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Estudios Parasitológicos y de Vectores (i); ArgentinaFil: Marcotegui, Paula Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Estudios Parasitológicos y de Vectores (i); ArgentinaFil: Alda, Maria del Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Estudios Parasitológicos y de Vectores (i); Argentin

    Consensus on nomenclature for clinical staging models in bipolar disorder : a narrative review from the International Society for Bipolar Disorders (ISBD) Staging Task Force

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    Objectives: Clinical staging is widely used in medicine to map disease progression, inform prognosis, and guide treatment decisions; in psychiatry, however, staging remains a hypothetical construct. To facilitate future research in bipolar disorders (BD), a well-defined nomenclature is needed, especially since diagnosis is often imprecise with blurred boundaries, and a full understanding of pathophysiology is lacking. Methods: Under the auspices of the International Society of Bipolar Disorders, a Task Force of international experts was convened to review, discuss, and integrate findings from the scientific literature relevant to the development of a consensus staging model and standardize a terminology that could be used to advance future research including staging of BD and related disorders. Results: Consensus opinion and areas of uncertainty or difference were identified in regard to terms referring to staging as it may apply to BD, to at-risk status and subthreshold stages, and to various clinical stages of BD as it is currently diagnosed. Conclusion: The use of a standardized nomenclature about the clinical stages of BD will facilitate communication about research on clinical and pathological components of this heterogeneous group of disorders. The concepts presented are based on current evidence, but the template provided allows for further refinements as etiological advances come to light

    Lithium and bipolar depression

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    Kelly1 has recently disputed the recommendations of several international guidelines on the use of lithium in bipolar depression. In his scrutiny, the author points to three main errors that seem to have affected systematically ten international guidelines, namely the Woozle effect (evidence by citation), reference inflation (inappropriate citation of pivotal, generally old, studies) and belief perseverance (inability to modify evidence‐based recommendations despite the presence of contrary data). We concur with the author that the evidence supporting the effectiveness of lithium in acute bipolar depression, and to a lesser degree also in major depressive episodes, remains inadequate.2, 3 A different matter is, in our opinion, to label guidelines recommendations as inaccurate or biased, even if, as the author stated, no deceptive intentions were present
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